The Buffalo Bills hosted the Indianapolis Colts for their first of three preseason games on Saturday afternoon.

The Buffalo Bills came back and defeated the Indianapolis Colts, 27-24, in their first preseason contest of 2022.

It was Keenum's first game as a Bill, which was the same for many others on offense.

Love and Basham both had sacks against the Colts. 

Johnson flashed his inner Jordan Poyer with some nice stops near the line of scrimmage.

Keenum and the offense did a good job of moving the ball down the field during their first drive

Buffalo turned the ball over five total times, the last one being an interception by Barkley.

The Bills put Shakir out to return the first punt, which also was the Bills’ first penalty of the year.